For exploring a sustainable development path of national park, Gansu area in Qilian Mountain National Park is investigated according to the relative statistic data for 2009 similar to 2019. In this work, the driving force-state-response (DFSR) model is used to construct the evaluation index system, and analyzing coupled coordination development between ecological environment and regional economic systems for Qilian Mountain National Park. The results show that the ecological environment and regional economy in Gansu area of Qilian Mountain National Park have been in a high level coupling stage in 2010 similar to 2019. The coupling degree of the two subsystems is high, the degree of interaction is strong, and the correlation is great. The coordination degree of ecological environment and regional economy of national parks increased steadily in 2010 similar to 2014, slow growth in 2014 similar to 2016, increased steadily again in 2016 similar to 2019. The development mode transform into a well coordinated development mode in 2019 from borderline disorder decline in 2010. Through the comparative analysis of the comprehensive evaluation value of the two sub-systems, it is found that the ecological environment and regional economy have not yet reached the optimal mode of eco-economic synchronous development. So we should look for new economic growth points while paying attention to environmental protection, so as to achieve the best development status as soon as possible. The grey model predicts that high-quality and coordinated development will be achieved in 2022, but economic development is slightly behind ecological protection.