Open-pit coal mining poses a severe threat to regional ecological security. Rapid and accurate monitoring of ecological quality changes is crucial for regional ecological restoration. In this study, taking the Wujiata open-pit coal mine as an example, the Red-Edge Normalized Difference Vegetation Index (RENDVI), Salinity Index (SI-T), WETness index (WET), Normalized Differential Built Soil Index (NDBSI), Land Surface Temperature (LST), and Desertification Index (DI) were used to construct the Open-pit Mine Remote Sensing Ecological Index (OM-RSEI) through Principal Component Analysis (PCA). The ecological quality and restoration conditions of typical mining areas in arid and semi-arid regions were monitored and evaluated. The results shown that: (1) The contribution rates and eigenvalues of OM-RSEI were higher than those of conventional RSEI, OM-RSEI was more applicable in open-pit mining areas. (2) From 2018 to 2023, the OM-RSEI of the Wujiata open-pit coal mine showed a 'V' shaped fluctuation that was damaged and then gradually recovered. (3) The degraded area of Wujiata open-pit coal mine and its 5 km buffer zone accounted for 78.02%, and the improved area accounted for 19.16%. (4) The average Moran's I index of OM-RSEI in the study area was 0.8189, and the high-high clustering corresponded to the 'good' and 'excellent' distributions, while the low-low clustering corresponded to the 'poor' and 'less-poor' distributions. The OM-RSEI provided a new indicator for monitoring and evaluation of ecological restoration in open-pit coal mines, which can provide theoretical support for ecological restoration in open-pit coal mining areas.