In the Desert-Gobi-Desertified land environment, the power transmission infrastructure faces the imminent threat of wind-sand disasters, which can result in transmission interruptions and significant economic losses. Currently, this issue has received limited scholarly attention, making it urgent to establish a sand prevention system tailored to the characteristics of transmission corridors. Through field investigation, it is found that there are two primary wind-sand disaster forms: wind erosion and sand accumulation. Drawing on research findings from sand control in desert traffic engineering and the specific features of transmission corridors, we propose principles and concrete measures for effective sand prevention. Finally, we apply these principles to the 750 kV transmission line project around Minfeng-Qiemo Utilizing ERA5 data and multi-period remote sensing images, we obtain more accurate information about the wind-sand environment and dune movements, providing a robust theoretical basis and technical support for sand control design. Our research offers valuable theoretical guidance for the sand prevention design of transmission corridors in desert areas and serves as a reference for other infrastructure projects (such as agriculture) facing similar challenges.