Dust emissions significantly impact the radiation balance, ecosystems, human health, and global climate change through long-range transport. However, their spatiotemporal characteristics and driving mechanisms in East Asia remain poorly understood. This study integrates multi-source reanalysis and remote sensing data (1980-2023) to analyze dust emissions across East Asian source regions using statistical methods and SHapley Additive exPlanations (SHAP) interpretability. The results show significant spatial and seasonal variations, with peak emissions occurring in spring (March-May). The Taklamakan Desert (S4) accounts for 38.1% of total emissions and is the largest source region. Meteorological factors are the main drivers (49.4-68.8% contribution), while climate indices contribute the least (2.9-8.0%). Wind speed is the most critical factor driving dust emissions, showing a significant positive correlation and interacting with 850 hPa geopotential height and boundary layer height. The driving factors of dust emissions vary across regions. In Mongolia (S1), dust emissions are mainly influenced by wind speed and atmospheric circulation, while in S4, near-surface meteorological conditions play a dominant role. In the Tsaidam Basin and Kumutage Desert (S5), as well as the Badain Jaran, Tengger, and Ulan Buh Deserts (S6), dust emissions are primarily driven by wind speed and boundary layer height, with atmospheric circulation also playing a certain role. Relative humidity shows a significant negative correlation with dust emissions in S5 and S6, while snowmelt and soil temperature have significant impacts on S4 and S5. The negative phases of the Arctic Oscillation and North Atlantic Oscillation enhance cold air activity and wind speed, significantly promoting dust emissions in S1 and S6. This study quantifies the mechanisms of dust emissions in East Asia and offers scientific support for improving climate models and developing disaster mitigation strategies.