Reservoirs are the primary source of water supply in the semiarid region of Pernambuco state, Brazil, because of the constant water scarcity affecting this region. Knowledge of the amount of water available is essential for the effective management of water resources. The volume of water stored in the reservoirs is calculated using the depth-area-volume relationship. However, in most reservoirs in the semiarid region, this relationship is currently out of date. Therefore, the objective of this study was to explore the potential and limitations of the application of the ISODATA unsupervised classification method to calculate the depth-area-volume relationships of reservoirs in the semiarid region of Pernambuco, Brazil. The application of the ISODATA method was evaluated in three reservoirs in the state of Pernambuco, i.e., Poco da Cruz, Barra do Jua, and Jucazinho. The results were compared with the updated curves of reservoirs obtained from bathymetry and recent LiDAR surveys. The ISODATA method presented satisfactory results for the three reservoirs analyzed. The mean absolute error of the volume in Poco da Cruz and Barra do Jua was lower than 1% of the maximum capacity. The use of the ISODATA method meant that the surface area underestimation tendency in the Poco da Cruz reservoir was less than when spectral indices were used.