In arid and semi-arid regions, unregulated land use changes as a result of poor planning, and the expansion of agricultural and livestock activities increase the risk of desertification and other potentially severe environmental impacts. Several consequences of improper land management practices are soil deterioration and erosion, which may be intensified by meteorological events. This paper presents a historical evaluation of the temporal and spatial evolution of soil deterioration in the southern Chihuahuan Desert in Mexico. A multi-temporal analysis of the study area during the 1995-2016 period was carried out using satellite data (Landsat series). Two seasons were analyzed to determine the influence of external events such as rainfall and wind: dry and rainy. The identification of soil conditions was based on the Brightness Index (BI) considering the complete satellite data set. The soil conditions were classified into five categories according to their reflectance values: highly deteriorated, deteriorated, in the process of being deteriorated, in good condition and other (clouds, water, non-soil). The change detection maps clearly show a growing trend wherein areas of deteriorated and eroded soil increase over time. Agriculture and strong winds are the two main factors involved in the soil deterioration process of the study region.