Cactus pear cladodes processing has potential value for mainstream industries and is equally important for marginal rural communities in arid regions. This work is focused on physico-chemical and rheological properties of Opuntia ficus-indica (OFI) peeled cladodes extracted by conventional method "CE" and using microwave-assisted extraction "MAE." MAE gave the highest yield extraction (8.13 %, w/w) within the lowest extraction time (500 W/7 min) and provided more protein (x1.03) and carbohydrates (x1.51) than CE. The monosaccharides detected by gas chromatography were arabinose, galactose, rhamnose, xylose, and galacturonic acid. The dialyzed mucilage solution characterized by SEC/MALS/VD/DRI (size-exclusion chromatography coupled with online multi-angle light scattering, viscometer detectors, and differential refractive index) revealed fractions with molecular weight (M (w) ) ranging from 15.3-15.7 x 10(6) g mol(-1) for the CE extracts and about 16.7-17.5 x 10(6) g mol(-1) for the MAE extracts. Dynamic oscillatory testing has been used to study the rheological properties of mucilage solution within the concentration of 0.50-3.00 % (w/v) at 25 A degrees C. The rheological profiles of CE and MAE showed similar behavior. At low frequency and low mucilage concentration (< 2.00 %), the viscous component (G") predominated over the elastic component (G'), while for higher frequencies, the behavior is reversed (G' > G"). If safely controlled, alternative energies like microwaves could extract soluble polymers with comparable properties to commercial ones, conventionally extracted.