An investigation was carried out to compare the A(4(M)) CMS (cytoplasmic-nuclear male-sterility) system to the widely used A(1) CMS system in sorghum (Sorghum bicolor (L.) Moench) for agronomic traits and panicle grain mold resistance (PGMR) score at International Crops Research Institute for the Semi-Arid Tropics (ICRISAT), Patancheru, Andhra Pradesh, India in 2006 and 2007 rainy and postrainy seasons. The cytoplasm per se and its first order interaction with A-line seemed to contribute to grain yield, male-fertility restoration % and PGMR during rainy season and male-fertility restoration per cent during postrainy season. The mean days to 50% flowering, plant height and grain yield of A(4(M)) cytoplasm-based hybrids were comparable with those of A(1) cytoplasm-based hybrids during 2006 and 2007 postrainy seasons while during 2006 rainy season, A(4(M)) cytoplasm based hybrids in few nuclear backgrounds were significantly superior to A(1) cytoplasm based hybrids for early flowering and grain yield, while in few nuclear backgrounds A(1) cytoplasm-based hybrids were superior. However, the A, cytoplasm based hybrids were more tolerant for grain mold. Hence the A(4(M)) cytoplasm can be used to incorporate genetic diversity in grain sorghum hybrids for grain yield in postrainy season, but its use in rainy season is not recommended, where grain mold poses a problem.