The sustainability of groundwater resources in semi-arid regions is increasingly under threat due to rising water demands resulting from population growth and agricultural expansion. Therefore, it is crucial to accurately identify recharge zones for effective management. This study maps the potential for groundwater recharge in El Kef region of north-western Tunisia using an integrated approach that combines remote sensing techniques (RST), geological and hydrogeological datasets and the Analytical Hierarchy Process (AHP). Seven key parameters, including lithology, lineament density, ground slope, soil texture, precipitation, land use/land cover (LULC), and drainage density, were analyzed and weighted using the AHP, with thematic layers integrated through weighted overlay analysis in ArcGIS to generate a Groundwater Potential Zones Map (GWPZ). Results reveal that 42.8% of the study area shows high recharge potential, concentrated in zones with favorable lithology, permeable soils, and low-gradient topography that promote infiltration under semi-arid conditions, while 35% has moderate potential and 22.2% occurs in low-potential zones dominated by impermeable clay formations and steep slopes. Bounded uncertainty envelopes of 38.2-43.5% (high), 33.7-39.5% (moderate), and 21.7-22.7% (low) are determined by the one-factor-at-a-time sensitivity analysis. Multi-tracer validation using piezometric levels, well yields, tritium, delta 2H, total dissolved solids, and nitrate concentrations, shows strong correspondence between mapped high-recharge zones and areas of elevated groundwater productivity and recent recharge signatures. These findings provide a spatially explicit framework for prioritizing groundwatermanagement interventions, including artificial-recharge site selection and aquifer-protection strategies, with direct applicability to other semi-arid regions worldwide that face similar groundwater-depletion pressures.