Ultraviolet (UV) radiation is a public health issue, especially in tropical and subtropical regions, where intense solar exposure contributes to a higher incidence of skin cancer. The growing concerns surrounding synthetic UV filters have prompted the search for natural and sustainable alternatives. The Brazilian semi-arid region represents a unique ecosystem whose flora harbors bioactive metabolites that exhibit remarkable potential for pharmaceutical and cosmetic innovation. This study investigated the chemical composition, antioxidant capacity, and photoprotective properties of two Evolvulus species (Convolvulaceae Juss.) native to this biome: E. frankenioides and E. glomeratus. Total phenolic and flavonoid contents were quantified using the Folin-Ciocalteu and aluminum chloride methods, while antioxidant activity was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays, and the sun protection factor (SPF) was determined using the Mansur method. E. glomeratus exhibited higher phenolic content (172.61 mg GAE g-1), stronger antioxidant activity, and superior SPF (13.89) compared to E. frankenioides. Both extracts exceeded the minimum SPF threshold required by regulatory agencies. Highperformance liquid chromatography with electrospray ionization mass spectrometry (HPLC-ESI-MS) analysis identified 19 phenolic compounds, mainly flavonoids and chlorogenic acids, which likely account for these effects. Overall, the results highlight the potential of E. glomeratus as a promising source for the development of natural, effective, and environmentally sustainable photoprotective formulations.