Water resources in arid oases are extremely scarce, and the quality of irrigation water and groundwater depth are key factors affecting soil secondary salinization and maintaining high and stable crop yields. This study focuses on the oasis irrigation area of the 38th Regiment in Qiemo County, located in the extremely arid region at the southeastern edge of the Tarim Basin. For the first time, irrigation experiments with different water qualities, ranging from 0.5 to 3.0 g/L, were conducted under varying groundwater depths for multiple crops. Through indoor soil column experiments and numerical simulations of water and salt in the unsaturated zone, the study reveals the water and salt migration patterns in the root zones of watermelon, corn, jujube, and peanuts. It was found that the process of soil water and salt transport exhibits significant differentiation characteristics in the vertical direction, with the surface layer responding most rapidly to changes in moisture and salinity, while the middle and deep layers show certain lag and buffering effects. The study also examined the spatiotemporal distribution trends of soil water and salt under different water quality and quantity irrigation conditions, drawing nonlinear threshold response curves for groundwater depth and determining the optimal groundwater depth under various irrigation conditions. The results indicate: (1) for the four crops under freshwater (0.5 g/L) irrigation and actual irrigation water conditions, soil salinity is safe at groundwater depths of 1-2 m; (2) under slightly saline water (2.0 g/L) irrigation, the safe groundwater depth (GWD) ranges for corn, peanuts, watermelon, and jujube root zones are 3.5-4.2 m, 1.2-3.5 m, >= 2.9 m, and >= 1.6 m, respectively, with crop sensitivity ranking as "corn > peanuts > watermelon > jujube"; and (3) under saline water (3.0 g/L) irrigation, the salinity tolerance thresholds for corn and peanuts root zones are exceeded regardless of shallow or deep groundwater depths, while the upper limits of salinity tolerance thresholds for watermelon and jujube correspond to groundwater depths of 2.9 m and 2.1 m, respectively, with increased groundwater depth making soil salinity increasingly safe. The study proposes a "sensitive-suitable-reinforced" three-zone paradigm and constructs a threshold table for optimal crop layout in arid areas based on the synergistic dual factors of "water quality-water quantity," providing a theoretical basis for crop layout considering the spatial heterogeneity of groundwater occurrence. This has guiding value for arid oases in addressing the dual stress of water quality deterioration and salinization.