Expanding desiccated lakebeds in arid and semi-arid regions are critical dust-emission hotspots, driven by climate change and unsustainable water use. Biological soil crusts (biocrusts), formed by cyanobacteria, offer a promising nature-based solution for stabilizing these vulnerable surfaces, yet the optimal inoculum density for effective erosion control remains poorly defined. This study evaluated the dose-response effects of native Nostoc sp. and Oscillatoria sp., isolated from the dried bed of Lake Urmia, Iran, applied at 0, 1, 3, and 6 g m-2 on biocrust development and wind erosion resistance under controlled conditions. After 120 days of incubation, trays were exposed to simulated wind erosion (72 km h-1 for 30 min). A strong, nonlinear dose-dependent reduction in soil loss was observed: erosion decreased by 28.1%, 66.7%, and 99.4% at 1, 3, and 6 g m-2, respectively, compared to the control (61.73 kg m-2). The highest dose nearly eliminated erodibility. Inoculation significantly enhanced biocrust formation, increasing crust thickness (1.36-6.65 & times;), chlorophyll-a (1.8-5.2 & times;) and microbial respiration (1.6-6.4 & times;). Scanning electron microscopy revealed dense filamentous networks binding soil particles into cohesive aggregates. These results identify 6 g m-2 as a practical saturation point for near-total erosion suppression and robust biocrust development. These findings provide a mechanistic, dose-optimized framework for cyanobacterial inoculation as a scalable restoration tool in degraded arid and semi-arid lands. Field-scale validation is now essential to translate this laboratory breakthrough into landscape-level dust mitigation and land rehabilitation strategies.