In the present study, sisal (Agave sisalana) defibration residue was used as a raw material to obtain fermentable sugars and phenolic compounds through integrated processes. Hydrothermal pretreatments under different temperature conditions (160, 180, and 200 degrees C) and incubation times (30, 60, and 90 min) were performed to promote cellulose enrichment and, consequently, enzymatic digestibility. The enzymatic hydrolysis residue was then used as a precursor for phenolic compounds via alkaline hydrolysis, evaluating the effects of sodium hydroxide concentrations (2%, 4%, and 6%, w/v) and hydrogen peroxide concentrations (0%, 1%, and 2%, v/v). In general, increasing pretreatment severity led to greater losses of extractives, ash, and hemicellulose at the expense of increased cellulose content and crystallinity index. The best pretreatment condition was 180 degrees C for 60 min, which increased cellulose content from 16.43% to 38.91% and glucose release from 3.0 to 17.2 g/L (conversion = 79.7%) at 5% solids. Under high solid loadings, enzymatic hydrolysis of pretreated sisal residue was also successful, yielding glucose levels above 90 g/L (at 30% solids). The production of phenolic compounds (mainly vanillin) was achieved by increasing sodium hydroxide and eliminating hydrogen peroxide, reaching a maximum concentration of 2,115.6 mg/L using 4% sodium hydroxide and 20% solids. Therefore, this study contributes to understanding the potential of sisal as a precursor to value-added products and may contribute to the development of technologies using plants from arid zones.