Soil salinization is a global environmental concern that threatens food and nutritional security. In this study, the effectiveness of integrating a raised-bed planting system, mulching and drip irrigation for managing soil salinity was investigated in a wheat field experiment conducted from 2019 to 2020 and 2020-2021. The experimental design included two planting methods, namely, (a) flat-bed planting (FB) and (b) raised-bed planting (RB) methods along with rice straw mulch application. Furthermore, saline water at four salinity levels was applied in the subplot treatments via a drip irrigation system, with ECiw values of (i) 12 dS m(-1), (ii) 9 dS m(-1), and (iii) 6 dS m(-1), as well as (iv) the best available water (BAW, similar to 4 dS m(-1)), which served as a control. The findings revealed that the integration of drip irrigation, mulching, and the RB system favourably affected the soil-plant environment. The RB system not only increased the soil moisture content but also significantly reduced surface salinity by redistributing soluble salts towards bed slopes and furrows, thereby maintaining a relatively low salt concentration in the crop root zone. Additionally, the RB mulched drip-irrigated system yielded greater nitrogen (NO3-N) availability, leaf area index (LAI) and canopy density levels. These favourable changes increased the grain yield, water productivity, net income and water economic productivity, which increased by 7%, 4.22%, 9.22% and 9.14%, respectively, compared with those in the FB mulched drip-irrigated system. This study revealed that the integration of drip irrigation, residue mulching, and RB systems could sustain crop production in arid and semiarid regions facing acute shortages of good-quality irrigation water.