'GoWheat 9216H' (Reg. no. CV-1224, PI 708101) is a hard red winter wheat (Triticum aestivum L.) that was bred and released by the Texas A&M AgriLife Research Wheat Improvement Program in 2021. GoWheat 9216H is an F4-derived line advanced from the cross 'X09A440S' ( = TX07A001482/TAM 401)/'Duster' that was made in Bushland, TX, in 2010. GoWheat 9216H is a medium-maturing, semi-dwarf, awned and white glumed wheat that has demonstrated high grain yield potential across many Texas environments in both irrigated and dryland conditions. GoWheat 9216H is resistant to stem rust (Sr; Puccinia graminis Pers.:Pers f. sp. tritici Erikss. & E. Henn.), leaf rust (Lr; P. triticina Erikss.), and stripe rust (Yr; P. striiformis Westend. f. sp. tritici Erikss.), with marker data suggesting it carries Lr34, Lr37, Lr68, Yr17, Yr18, YrM1225, and Sr38. It is moderately resistant to Hessian fly [Mayetiola destructor (Say)]. This cultivar shows good baking and milling quality traits equivalent to high-quality checks and further features large seeds and high grain volume weight. Its height is similar to that of recently released Texas A&M cultivars, but it has a later maturity date. GoWheat 9216H is poised to perform well under both irrigated and dryland conditions in the Texas Rolling Plains, South and Central Texas, and the Blacklands, as well as in other regions across the state with similar adaptation zones.