Global ecosystems have undergone significant degradation and deterioration, making the identification of ecosystem changes essential for promoting sustainable development and enhancing quality of life. Hami City, a representative region characterized by the complex "desert-oasis-mountain" ecosystem in Xinjiang, China, provides a critical context for examining ecosystem changes in extremely arid environments. This study utilizes remote sensing data alongside the Revised Wind Erosion Equation and Revised Universal Soil Loss Equation models to analyze the transformations within the desert-oasis ecosystems of Hami City and their driving forces. The findings reveal that (1) over the past 24 years, there have been substantial alterations in the ecosystem patterns of Hami City, primarily marked by an expansion of cropland and grassland ecosystems and a reduction in desert ecosystems. (2) Between 2000 and 2023, there has been an upward trend in Fractional Vegetation Cover, Net Primary Productivity, and windbreak and sand fixation amount in Hami City, whereas soil retention has shown a declining trend. (3) The overall ecosystem change in Hami City is moderate, encompassing 61.85% of the area, with regions exhibiting positive change comprising 16.79% and those with negative change comprising 21.33%. (4) Temperature, precipitation, and evapotranspiration are the primary drivers of ecosystem change in Hami City. Although the overall changes in ecosystems in Hami City have shown an improving trend, significant spatial heterogeneity still exists. The natural climatic conditions of Hami City constrain the potential for further ecological improvement. This study enhances the understanding of ecosystem change processes in extremely arid regions and demonstrates that strategies for mitigating or adapting to climate change need to be implemented as soon as possible to ensure the sustainable development of ecosystems in arid areas.