Vitamin C industrial residue after evaporation (RAE) acts as both a rapid-release carbon source and a microbial activity promoter. A two-year maize field experiment assessed the effectiveness of RAE in improving soil quality in degraded semi-arid regions. The RAE formulation was applied via drip irrigation during the sixth true leaf unfolded (BBCH 24), fourteenth true leaf unfolded (BBCH 38), and middle of grain filling (BBCH 66) stages, which consisted of three treatments: (1) untreated control (CK), (2) low RAE rate (LR: 150 L/ha), and (3) high RAE rate (HR: 300 L/ha). Soil physicochemical properties, enzyme activities, maize nutrient accumulations, and yields were comprehensively analyzed at the maize maturity stage. RAE application significantly improved the following soil nutrients: dissolved organic carbon (10.40-25.92%), ammonium nitrogen (14.04-70.67%), nitrate nitrogen (14.80-78.63%), and available phosphorus (11.79-42.55%). Soil enzyme activities also increased: sucrase (12.38-30.25%), amidase (1.95-25.69%), peptidase (0.56-48.79%), beta-1,4-N-acetylglucosaminidase (3.11-9.48%), protease (17.41-226.29%), and acid phosphatase (8.73-60.04%). These changes enhanced maize nitrogen (17.63-40.73%) and phosphorus (20.09-42.11%) uptake, increasing yield by 7.12-13.46%. Statistical analysis showed strong correlations between yields and nutrient accumulations (r = 0.82, p < 0.01), particularly phosphorus (r = 0.91, p < 0.001). RAE enhances crop productivity in degraded agricultural systems by improving soil nutrient availability and plant assimilation, making it a viable alternative to conventional fertilizers.