This study integrates dynamic energy simulation with lifecycle assessment (LCA) to evaluate the energy and carbon performance of advanced glazing systems suitable for hot-arid climates. Using Design Builder software coupled with OpenLCA, six glazing configurations were analyzed under identical building and climatic conditions. The configurations included a conventional single 3 mm float glass pane (C0) as the reference case, a single 3 mm polycarbonate sheet (C1) representing common local construction practice, and four advanced multi-layer systems (C2-C5) incorporating air, argon, and nanogel insulation layers. The inclusion of C0 enabled direct comparison between typical glass construction and emerging polycarbonate-based systems, thereby enhancing the contextual relevance of the analysis. Results demonstrated that thermal and optical properties of glazing systems strongly influence both operational and embodied carbon outcomes. Relative to the conventional glass reference (C0), the nanogel-argon composite (C5) achieved a 32.4% reduction in annual cooling energy and a 28.9% decrease in total lifecycle carbon emissions, with a carbon payback period of approximately 1.1 years. The operational phase dominated total emissions (>97%), confirming that improvements in glazing thermal performance yield substantial long-term benefits even when embodied impacts are considered. While argon filling provided marginal benefit over air cavities, the nanogel insulation contributed the largest performance enhancement. However, the relatively low visible light transmittance (VLT = 0.27) of the C5 system suggests a potential daylight-comfort trade-off that warrants further investigation. The study demonstrates the importance of integrating energy simulation with lifecycle assessment to identify glazing systems that balance energy efficiency, embodied carbon, and indoor environmental quality in hot-arid regions.