Salinity-induced edaphic stressors are the major factors affecting nutrient availability and crop productivity in arid and semi-arid regions worldwide. The fungal isolates native to salt-affected soils can offer an effective solution for stress mitigation and ensuring plant nutrition. Fungal isolate Talaromyces sp. strain ST1 demonstrated appreciable P and Zn solubilization, ammonia, hydrogen cyanide (HCN), siderophore, and indole acetic acid production along with salt, temperature, and alkalinity tolerance. Germination assay of wheat, pearl millet, sorghum, and mustard were tested with in vitro growth promotion by Talaromyces. Further, a pot experiment with Talaromyces ST1 inoculated sorghum was conducted for 70 days of growth in saline soils of different salinity. Sorghum roots secreted extracellular enzymes and improved seed germination under salinity. The fungal mycelium grown on tricalcium phosphate (TCP) enriched media contained P content in the range of 1.11-2.11% compared to the mycelium from the growth medium without TCP (0.37-0.55%). The biopriming of seeds with Talaromyces sp. strain ST1 increased P content and uptake in aboveground biomass of sorghum by 4.2 - 18.4 and 21.3 -34.8%, respectively, under saline soils (ECe 4-12 dS m-1). The fungal inoculation caused a 22.3-59.1% decline in the Na: K ratio at different salinity levels. The strain ST1 inoculation increased the Olsen's-P by 8.8-18.3% at all salinity levels with an associated decline in the organic (2.7-24.1%), inorganic (5.7-61.3%) and calcium bound (3.4-5.7%) P-pools. The Al-P, Fe-P, organic-P, Ca-P, alkaline phosphatase, and dehydrogenase activities described about 90% variability in plant growth, biomass production, and P-nutrition. The salt-tolerant Talaromyces sps. strain ST1 can be a potential biostimulant for stress mitigation and crop nutrition under salt - affected agroecologies for higher P - solubilization and plant growth promotion.