Identifying groundwater potential zones in arid regions is crucial in mitigating depletion and enhancing the sustainability of water resources and food security. To develop an effective groundwater management framework for fractured aquifers in these regions, a thorough understanding of the site's conceptual flow model is crucial for ensuring irrigation water sustainability. It is essential to discern the groundwater potential zones (GWPZs) that have a high likelihood of accessing groundwater resources. This study aims to establish an integrated framework for mapping GWPZs in fractured limestone aquifers by capitalizing on remote sensing (RS) and surficial Direct Current (DC) resistivity data within a Geographic Information System (GIS) environment. By harmonizing surface (precipitation rates, lineament density, watershed, drainage system, land use) and hydrogeophysical data (layer thicknesses, aquifer resistivity, overburden infiltration capacity, and buried geologic structures), this holistic approach aspires to enhance the understanding of hydrogeological frameworks in limestone aquifers, encompassing geological features, hydrological pathways, and hydraulic properties. Focused on the southeastern Beni Suef area, the current findings pinpoint groundwater zones and provide insights into groundwater movement and recharge mechanisms. The area highly suitable for artificial recharge spans 53.71 km2 (41 %), whereas the good and low-suitability zones cover 29.98 km2 (23 %) and 43.30 km2 (33 %), respectively. The resulting framework exhibits potential for broader applications in analogous arid regions, streamlining groundwater exploration, fostering artificial recharge strategies, and promoting sustainable water resource management practices on a global scale. Ultimately, this research not only aids local decision-makers in optimizing groundwater use but also contributes to international efforts to achieve sustainable development goals related to water security and environmental resilience.