Climate change is associated with the intensification of weather patterns, including extreme weather events of historically arid regions such as the United Arab Emirates (UAE). On April 16-17, 2024, the UAE experienced a severe storm with unusually heavy precipitation, which resulted in widespread urban flooding, contaminated floodwaters, and the potential for cross-contamination in water distribution systems. Ten floodwater samples from around the American University of Sharjah, UAE, were analyzed for the presence of emerging contaminants (e.g., tire-derived chemicals, pharmaceuticals, and personal care products (PPCPs)) and selected metals. Tire-derived chemicals were detected at varying concentrations: N-(1,3-Dimethylbutyl)-N '-phenyl-p-phenylenediamine (6PPD) (g/L), iron (49-349 mu g/L), potassium (160-3860 mu g/L), manganese (3 mu g/L), and barium (1-7 mu g/L). Correlation analysis revealed a strong positive correlation between 6PPD-quinone and HMMM (r = 0.893, p = 0.000507), and among acetaminophen, caffeine, cotinine, and lidocaine (r = 0.501-0.980, and p < 0.05), suggesting shared sources stemming from high vehicular activity and raw wastewater overflow. These findings emphasize the need for arid regions to implement targeted stormwater management and monitoring strategies during extreme weather events to address floodwater-driven mobilization of environmental contaminants.