Natural hazards have led to livelihood insecurity, poverty, and infrastructure destruction in arid regions. It is essential to enhance the farmers' resilience to current and future hazards. In this respect, understanding adaptive strategies that increase the farmers' resilience is imperative. The present qualitative research was conducted to identify adaptive strategies for farmers of the Sistan Plain (Iran) to enhance their resilience to hazards. Data were collected through in-depth and semi-structured interviews with experts, observation, and field notes. The results revealed drought, dust storms, and floods as the major hazards farmers face in this area. The adaptive strategies to drought could be divided into technical-agricultural management, water resources management, livelihood, and legal-infrastructure factors. In addition, strategies for enhancing farmers' resilience to floods included infrastructure, technical, and livelihood management strategies. Also, the findings indicated that dealing with the dust storms requires applying technical, economic, legal, and infrastructure strategies. Risk management, good water governance and water diplomacy, accelerating economic growth, developing non-farm and small-scale enterprises, building capacity and empowering rural families, and strengthening infrastructures can enhance resilience to natural hazards in Sistan Plain.