Wheat (Triticum aestivum L.) is globally the third cereal crop, predominantly cultivated in arid and semi-arid areas, making it particularly susceptible to various biotic and abiotic stresses. Cyanobacteria contributed to wheat growth by soil fertility, plant nutrition and stress tolerance. The current study was conducted to assess to evaluate the growth, biochemical attributes, elemental composition (N, P, K and Organic matter), production of wheat plant grown in saline-alkaline soils amended with various abiotic stresses (heat, drought, salt and the combination of salt, heat and drought (SHD)), and blue green algae bio-fertilizer (Anabaena azotica (A.A), Nostoc flagelliforme (N.F), and combination of A.A + N.F). The combined applications resulted in the highest increase in plant length, leaf fresh weight and leaf dry weight, demonstrating enhanced growth and vigor under these conditions. Antioxidant enzyme activities were highest under SHD treatment, indicating an enhanced defensive response against oxidative stress induced by multiple abiotic stresses. Total phenolic content (TPC), 2,2diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, and ferric reducing antioxidant power (FRAP) showed strong positive correlations (ranging from r = 0.82 to 0.88), indicating that these biochemical constituents enhance the plant's overall antioxidant capacity. These results highlighted the role of environmental stress and nitrogen-fixing strains in modulating secondary metabolite production in wheat, with combined stress treatments promoting the highest levels of bioactive compounds. This research contributes to the broader discourse on algal biotechnology and its role in advancing resilient agricultural systems.