Extreme drought events may become more frequent with climate change. Understanding the impact of extreme drought on grassland ecosystems is therefore crucial for the long-term sustainability of ecosystems. Here, we identified extreme drought events in the Inner Mongolia grasslands of China using long-term standardized precipitation evapotranspiration index (SPEI) data and evaluated drought resistance of the vegetation under extreme drought based on net primary production (NPP). The impact of consecutive extreme drought events and multiple discontinuous one-year extreme drought events on grasslands were further analyzed to investigate the response strategies of different grassland types to different drought conditions. We found that the frequency and area of extreme drought in 2000-2011 were significantly higher than those in 2012-2020, and the Xilingol League region showed the highest frequency of extreme drought events. Under extreme drought, vegetation resistance was positively correlated, where annual precipitation > 300 mm. The mean resistance of different grassland types followed the order: upland meadow (UM) > lowland meadow (LM) > temperate meadow steppe (TMS) > temperate desert (TD) > temperate steppe (TS) > temperate steppe desert (TSD) > temperate desert steppe (TDS). In the analysis of two cases of consecutive two-year extreme drought, all grassland types except TSD and TD showed obvious decreased resistance in the final drought year, with the highest reduction (0.16) in LM during 2010-2011, implying the widespread and significant inhibition of grassland growth by continuous drought. However, under the multiple discontinuous extreme drought events, the resistance of all grassland types showed a fluctuating but an overall increasing trend, suggesting the adaptability of grassland to drought. The results emphasize that management departments should pay more attention to regions with low resistance and enhance the stability of grassland production by increasing the proportion of drought-resistant plants in reaction to future extreme drought scenarios.