The main objective of this study is to improve indoor air quality by employing a solar-powered liquid desiccant system (LDS) to simultaneously reduce the temperature and humidity levels of supply air in buildings located in Algeria. Three representative climatic zones are considered: Mediterranean (Zone I, Algiers), semi-arid (Zone II, Djelfa), and Saharan (Zone III, Illizi). This work presents the first simulation-based assessment of a solar-driven LDS in Algeria, a country characterized by highly diverse climatic conditions. Unlike previous studies conducted in more homogeneous climates, this research demonstrates how system performance varies under contrasting environmental conditions, providing region-specific insights that can support future large-scale implementation.The LDS was modeled using TRNSYS software and consists of a dehumidification loop and a regeneration loop coupled with a solar collector. Two system configurations were analyzed: adiabatic (AD) and internally cooled (INT). The latent load reduction for the AD configuration ranged from 27% to 87%, while for the INT configuration it varied between 47% and 100%. The sensible load reduction for the INT configuration ranged from 2% to 5%. These reductions correspond to periods characterized by high humidity and temperature levels across the three climatic zones. The absorber humidity decreased from 0.1 gw kgda-1 to 2.5 gw kgda-1 in the AD configuration. In the INT configuration, the air temperature and humidity were reduced by 5 degrees C and between 2 gw kgda-1 and 5 gw kgda-1, respectively. Overall, the results indicate that the INT LDS is significantly more efficient than the AD configuration, making it a more suitable option for application in Algerian buildings.