Under global warming, drought frequency and its severity have risen notably, posing considerable challenges to vegetation growth. Central Asia (CA), recognized as the largest non-zonal arid zone globally, features dryland ecosystems that are particularly vulnerable to drought stress. This research examines how plant life in CA reacts to prolonged dry spells by analyzing multiple datasets, including drought indices and satellite-derived NDVI measurements, spanning four decades (1982-2022). This study also delves into the compound impact of drought, revealing how its influence on vegetation unfolds through both cumulative stress and delayed ecological responses. Based on the research results, the vegetation coverage in CA exhibited a notable rising tendency from 1982 to 1998. Specifically, it increased at a rate of 4 x 10(-3) per year (p < 0.05). On the other hand, the direction of this trend shifted to a downward one during the period from 1999 to 2022. During this latter phase, the vegetation coverage decreased at a rate of -4 x 10(-3) per year (p > 0.05). Vegetation changes in the study area underwent a fundamental reversal around 1998, shifting from widespread greening during 1982-1998 to persistent browning during 1999-2022. Specifically, 98.6% of the region underwent pronounced summer drought stress, which triggered a substantial rise in vegetation browning. The vegetation response to the accumulated and lagged effects of drought varied across seasons, with summer exhibiting the strongest sensitivity, followed by spring and autumn. The lagged effect of drought predominantly influences the vegetation during the growing season and spring, affecting 59.44% and 79.27% of CA, respectively. In contrast, the accumulated effect of drought is more prominent in summer and autumn, affecting 54.92% and 56.52% of CA. These insights offer valuable guidance for ecological restoration initiatives and sustainable management of dryland ecosystems.