This study examines the impacts of climate change on the distribution of four endemic North African plant species-Heteromera fuscata, Heteromera philaenorum, Thymelaea microphylla, and Genista microcephala-noted for their medicinal value. Using validated occurrence data and 19 bioclimatic variables, MaxEnt modeling was applied to simulate current and future distributions under four climate scenarios (SSP1-2.6, SSP2-4.5, SSP3-7.0, SSP5-8.5) for the 2030 s, 2050 s, 2070 s, and 2090 s. Spatial habitat changes were assessed via ArcGIS. Key environmental drivers identified included annual mean temperature (Bio1), mean temperature of the driest quarter (Bio9), and precipitation of the warmest quarter (Bio18). The models performed excellently, with AUC values between 0.982 and 0.989. Results indicate that northern North Africa will remain largely suitable for these species, with limited shifts overall. However, Heteromera philaenorum is projected to face significant habitat loss and a shift toward arid zones, with mountain areas serving as potential refuges. Habitat extent for Heteromera fuscata is expected to decline from 59.79 x 10' km2 to 34.53 x 10' km2 under SSP585, and Heteromera philaenorum from 50.42 x 10' km2 to 9.77 x 10' km2. Thymelaea microphylla's medium suitable habitat could decrease from 28.21 x 10' km2 to approximately 14 x 10' km2, while Genista microcephala's highly suitable area may expand from 46.56 x 10' km2 to over 67 x 10' km2. These findings illustrate varied species responses to climate change, emphasizing the need for targeted conservation strategies under warming conditions.