Understanding the responses of wildfires to long-term climate variability is critical for improving fire management strategies and maintaining ecological stability. However, the spatial heterogeneity and drivers of wildfires in the East Asian monsoon (EAM) region on orbital timescales remain poorly constrained. In this study, wildfire dynamics across the last five glacial-interglacial cycles were determined based on a similar to 480 kyr wildfire history reconstructed from black carbon (BC) records in the Huangshan loess-paleosol sequence in northeastern China. The results revealed substantial glacial-interglacial cycles in northeastern China, with more intense fires during interglacials than glacials. Comparative analysis with other wildfire records revealed notable spatial heterogeneity of wildfires across the EAM region on the glacial-interglacial timescale. Wildfires in the eastern East Asian monsoon (EEAM) region were more active during interglacials, likely due to higher temperatures and greater biomass availability. Conversely, those in the western East Asian monsoon (WEAM) region were more frequent during glacials because of fuel desiccation caused by reduced precipitation. Overall, the large-scale spatial precipitation pattern, which gradually decreased from southeast to northwest in the EAM region, may serve as the core driver of wildfire spatial heterogeneity. Under future global warming, the EEAM region will likely face elevated wildfire risks and should be prioritized for fire prevention.