Based on the loess topography and geomorphology of the Xihai Gu region (Xiji, Haiyuan, and Guyuan) and indoor experimental data, three-dimensional numerical models of loess ridge slopes and loess hill slopes were established to analyze differences in ground motion response and deformation of loess slopes with distinct landforms. Loess slopes (e.g., loess ridges, hills, and gully terrains) are ubiquitous across the Loess Plateau, where localized irregular topographies induce amplification and attenuation of seismic motions, thereby affecting slope stability.The study revealed that for the two generalized slope models, the peak ground acceleration (PGA) amplification factor reaches its maximum at the slope crest and its minimum near the loess-mudstone contact surface. Under identical seismic loading, the dynamic response of the loess hill slope is more pronounced than that of the loess ridge slope; under varying seismic loading conditions, the PGA amplification factor of the loess hill slope exhibits greater variability. The Fourier spectrum amplitude of the loess hill slope is greater than that of the loess ridge slope, with distinct predominant frequencies observed at the middle section of the two slope types. Under the action of ground motion, both slope models experience instability and failure: the maximum displacement of the loess hill slope is larger than that of the loess ridge slope; the maximum shear strain increment of the loess ridge slope takes place at the slope crest, while that of the loess hill slope occurs at the slope shoulder.The research results provide certain value for researchers engaged in the study of loess seismic landslides, offering insights into the influence of landform differences on loess slope seismic behavior and supporting the optimization of seismic stability evaluation and disaster prevention measures for loess slopes in the region.