Identifying the dominant mechanisms of water and soil salinization in arid and semi-arid endorheic basins is fundamental for our understanding of basin-scale water-salt balance and supports water resources management. In many inland basins, mineral dissolution, evaporation, and transpiration govern salinization, but disentangling these processes remains difficult. Using the Barkol Basin in northwestern China as a representative endorheic system, we sampled waters and soils along a transect from the mountain front through alluvial fan springs and rivers to the terminal lake. We integrated delta O-18-delta H-2 with hydrochemical analyses, employing deuterium excess (d-excess) to partition salinity sources and quantify contributions. The results showed that mineral dissolution predominated, contributing 65.8-81.8% of groundwater salinity in alluvial fan settings and similar to 99.7% in the terminal lake, whereas direct evapoconcentration was minor (springs and rivers <= 4%; lake <= 0.2%). Water chemistry types evolved from Ca-HCO3 in mountainous runoff, to Ca center dot Na-HCO3 center dot SO4 in groundwater and groundwater-fed rivers, and finally to Na-SO4 center dot Cl in the terminal lake. The soil profiles showed that groundwater flow and vadose-zone water-salt transport control spatial patterns: surface salinity rises from basin margins (<1 mg/g) to the lakeshore and is extremely high near the lake (23.85-244.77 mg/g). In spring discharge belts and downstream wetlands, the sustained evapotranspiration of groundwater-supported soil moisture drives surface salt accumulation, making lakeshores and wetlands into terminal sinks. The d-excess-based method can robustly separate the salinization processes despite its initial isotopic variability.