Soil secondary salinization is a major limiting factor of sustainable agricultural production in arid and semi-arid irrigation zones, yet predictive tools for regional water-salt dynamics remain limited. The Yichang Irrigation District, located within the Hetao Irrigation Area, has experienced persistent salinity challenges due to shallow groundwater tables and intensive irrigation. In this study, we aimed to simulate long-term soil water-salt dynamics in the Yichang Irrigation District and evaluate the effectiveness of different engineering and management scenarios using the SaltMod model. Field monitoring of soil salinity and groundwater levels during summer and fall (2022-2024) was used to calibrate and validate SaltMod parameters, ensuring accurate reproduction of seasonal soil salinity fluctuations. Based on the calibrated model, ten-year scenario simulations were conducted to assess the effects of changes in soil texture, irrigation water quantity, water quality, rainfall, and groundwater table depth on root-zone salinity. Our results show that under baseline management, soil salinity is projected to decline by 5% over the next decade. Increasing fall autumn leaching irrigation further reduces salinity by 5-10% while conserving 50-300 m(3).ha(-1) of water. Sensitivity analysis indicated groundwater depth and irrigation water salinity as key drivers. Among the engineering strategies, drainage system improvement and groundwater regulation achieved the highest salinity reduction (15-20%), while irrigation regime optimization provided moderate benefits (similar to 10%). This study offers a quantitative basis for integrated water-salt management in the Hetao Irrigation District and similar regions.