Pesticides are considered as a critical environmental problem, especially in semiarid areas like Siliana in Tunisia, where high seasonal temperatures often exceed 30 degrees C. These climatic conditions intensify evaporation, and economic limits delay the adoption of antidrift technologies. This study evaluates the effect of nozzle type, nozzle calibre and pressure on ground deposits, foliage retention and spray drift in cereal crops in Siliana, aiming to identify nozzle-calibre combinations that optimize treatment efficiency while minimizing environmental impacts. Field tests were conducted using a low-crop sprayer with two Albuz ISO flat-fan nozzles-110 degrees spray angle (a standard nozzle-APE (or API) and an antidrift nozzle-AVI), three calibres (11002, 11003 and 11006), at three pressures (200, 300 and 400 kPa). ANOVAs were performed to evaluate intervariable interactions. Regression models with high adjusted R-squared values (91%-98%) were developed to relate ground deposits, foliage retention and spray drift to nozzle, calibre and pressure. Simulations and field observations were combined to develop two decision-support guides and an optimization score enabling users to identify optimal nozzle-calibre-pressure combinations. Field results demonstrate that antidrift nozzle consistently outperforms the standard nozzle in minimizing losses and maximizing retention. When considering foliar retention as a major criterion for the treatment effectiveness, the antidrift nozzle 11002 combined with a pressure of 400 kPa achieved the highest retention rate (29%) and the lowest ground deposits rate (63%), with a moderate drift rate (8%). Model outcomes and developed decision-support guides validated the field findings, especially the superior performance of the antidrift nozzle. The optimization score achieved a quantitative ranking of the 18 studied nozzle-calibre-pressure combinations, in terms of improvement of foliage retention and losses reduction. The six top ranks corresponded to antidrift nozzle, and the best combination was antidrift nozzle combined with a calibre of 11002 and a pressure of 400 kPa, achieving an optimization score of 0.401.