Banana cultivation in T & uuml;rkiye's Mediterranean region is increasingly challenged by water scarcity, rising production costs, and environmental pressures. This study evaluated the economic performance of seven weed control strategies under two irrigation regimes-full (IR100) and deficit (IR50)-in greenhouse banana production. Conducted over two consecutive growing seasons (2022-2024) in Mersin, T & uuml;rkiye, the experiment compared four herbicide characters (Oxyfluorfen + Glyphosate + Diquat, Pendimethalin + Glyphosate + Diquat, Indaziflam + Diquat, and Glyphosate + Glyphosate + Diquat) with three alternative methods (mulching, mechanical control, and mowing). A cost-benefit analysis (CBA) approach was used to assess yield, gross profit, and cost-benefit ratio (CBR) as indicators of economic efficiency. Under deficit irrigation (IR50), mulching achieved the highest yield (3.632 kg da-1) and profitability (CBR = 1.04; Turkish Lira 4.043 da-1 gross profit), while the herbicide Glyphosate + Glyphosate + Diquat (G + G + D) also performed competitively (CBR = 1.02; Turkish Lira 1.923 da-1 gross profit). In contrast, mowing resulted in the weakest performance (CBR = 0.93; -Turkish Lira 5.223 da-1). Under full irrigation (IR100), all methods proved economically viable; however, mulching again outperformed the others (CBR = 1.46; Turkish Lira 43.033 da-1), followed by mechanical control (CBR = 1.41; Turkish Lira 35.490 da-1) and the Pendimethalin + Glyphosate + Diquat (P + G + D) herbicide applications, which emerged as the most effective chemical treatment (CBR = 1.39; Turkish Lira 32.700 da-1). Overall, the findings reveal that mulching offers the most sustainable and profitable weed control solution for greenhouse banana cultivation in semi-arid Mediterranean conditions, while P + G + D provides a reliable chemical alternative with strong and consistent economic outcomes. These results emphasize the importance of integrating efficient irrigation management with environmentally responsible weed control strategies to enhance resource-use efficiency and secure long-term farm profitability.