Sheep play a vital role in supporting rural livelihoods, especially in arid, semiarid, and marginal farming regions where crop and dairy production are less viable. This study evaluated the impact of Moringa oleifera leaf meal-based diets on the blood biochemical profiles of 'Deccani' sheep reared under intensive and semi-intensive systems. Thirty-six growing lambs (14-18 kg) were randomly allotted to three dietary treatments viz., T-1 (control), T-2 (75% groundnut cake + 25% Moringa leaf meal), and T3 (50% groundnut cake + 50% Moringa leaf meal) with six lambs per group in each system. The experiment lasted 90 days. Hematological and biochemical data were analysed using Student's t-test. No significant differences (P < 0.01) in hematological parameters were observed among the diets in either system. Hb concentrations ranged from 9.83 to 11.25 g dL-1 across the treatments, while PCV values were higher in T-2 than in T-1 and T-3. Total protein levels were significantly higher (P < 0.01) in T-3 in both systems. Glucose levels showed a non-significant decrease in T-2 as compared to T1 and T3. SGOT and SGPT values remained within the normal range. Overall, better blood biomolecule levels indicate that 25% Moringa inclusion under intensive rearing is superior to semi-intensive management.