China and Thailand possess a rich fungal biodiversity. In this study, we introduce four novel genera-Aquaguizhoumyces (Neohendersoniaceae), Biseriospora (Dactylosporaceae), Pseudocatenuliconidia (Vamsapriyaceae), Xenobactrodesmium (Savoryellaceae)-alongside 47 new species and three new habitat or distributional records. All newly described taxa are comprehensively documented through morphological characterization and relationships analyzed based on multigene phylogenetic analyses. The new species include: Acrogenospora hydei, A. keviniana, Acrohelicosporium hydei, Aquaguizhoumyces hydei, Berkleasmium hydei, Biseriospora hydei, Brachiosphaera hydei, Conioscypha davidii, C. hydei, C. keviniana, Cylindromonium hydei, Cyphellophora hydeae, Distoseptispora davidii, D. keviniana, D. polyblasta, D. pseudoaquisubtropica, D. solitaria, D. vaginae, D. velvetica, Fusichalara hydei, Helicoma kevinianum, Longiappendispora keviniana, Melomastia hydeae, Menisporopsis hydei, Neogaeumannomyces hydei, N. kevinifiliformis, Neohelicomyces davidii, Ne. kevinianus, Neohelicosporium hydei, Neo. kevinianus, Neomassaria davidii, Neom. hydeae, Neom. keviniana, Paramonodictys hydei, Pararoussoella hydei, Pleopunctum hydei, Pseudocatenuliconidia hydei, Pseudodactylaria hydei, Pseudorobillarda hydeana, Setophoma hydei, Sporoschisma hydei, Trichoderma guangxiensis, T. mashanense, T. zhongshanense, Tubeufia hydei, Vikalpa hydei, and Xenobactrodesmium hydei. Furthermore, we report two new habitat records for Rhodoveronaea hyalina and Hermatomyces xizangensis, as well as a new geographical and habitat record for Polyplosphaeria appendiculata. All taxa are supported by morphological and multigene phylogenetic analyses. This contribution is dedicated to Kevin D. Hyde in celebration of his 70th birthday, in recognition of his outstanding contributions to the field of mycology.