Highlights What are the main findings? A "hot zone" with higher surface temperatures and reduced vegetation cover emerged around Zonag Lake following its outburst. Downstream areas (from Kusai Lake to Salt Lake) exhibited significantly higher dryness levels compared to the upstream region. What is the implication of the main finding? The outburst-induced surface changes drive contrasting permafrost processes: desertification enhances permafrost development upstream, while wetting accelerates degradation downstream. This study provides critical insights for assessing environmental impacts and engineering safety in high-altitude permafrost regions under lake outburst events.Highlights What are the main findings? A "hot zone" with higher surface temperatures and reduced vegetation cover emerged around Zonag Lake following its outburst. Downstream areas (from Kusai Lake to Salt Lake) exhibited significantly higher dryness levels compared to the upstream region. What is the implication of the main finding? The outburst-induced surface changes drive contrasting permafrost processes: desertification enhances permafrost development upstream, while wetting accelerates degradation downstream. This study provides critical insights for assessing environmental impacts and engineering safety in high-altitude permafrost regions under lake outburst events.Abstract The outburst of Zonag Lake in the permafrost region of the Qinghai-Tibet Plateau (QTP) has significantly altered the local environment, particularly affecting surface conditions and permafrost dynamics. By employing remote sensing and GIS tools, this study analyzed the spatial and temporal variations in surface environmental changes (surface temperature, vegetation, and dryness) within the Zonag-Salt Lake basin. The results indicate that the outburst caused higher surface temperatures and reduced vegetation cover around Zonag Lake. Analysis using the Temperature-Vegetation Dryness Index (TVDI) reveals higher dryness levels in downstream areas, especially from Kusai Lake to Salt Lake, compared to the upstream Zonag Lake. Temporal trends from 2000 to 2023 show a decrease in average Land Surface Temperature (LST) and an increase in the Normalized Difference Vegetation Index (NDVI). Geographical centroid shifts in environmental indices demonstrate migration patterns influenced by seasonal climate changes and the outburst event. Desertification around Zonag Lake accelerates permafrost development, while the wetting environment around Salt Lake promotes permafrost degradation. The Zonag Lake region is also an ecologically significant area, serving as a key calving ground for the Tibetan antelope (Pantholops hodgsonii), a nationally protected species. Thus, the environmental changes revealed in this study carry important implications for biodiversity conservation on the Tibetan Plateau. These findings highlight the profound impact of the Zonag Lake outburst on the surface environment and permafrost dynamics in the region, providing critical insights for understanding environmental responses to lake outbursts in high-altitude regions.