In addressing desertification progress, there is a growing demand for utilizing saline water for food production. Therefore, our research focused for a new variety of halophyte, Suaeda edulis Flores Olv. & Noguez, which reported high productivity within the Suaeda genus. We aimed to elucidate its halophilic and salt-tolerant mechanisms. In hydroponic cultivation, S. edulis cultivated under conditions ranging from Na-free to 1,000 mol m-3 NaCl. The optimal concentration was 250 mol m-3, and the species exhibited tolerance up to 750. We assessed if it could acclimate to stress by sampling at 14 and 33 days. In S. edulis, the difference in fresh weight between Na-free conditions and optimal salinity was notably larger than in other Suaeda species, indicating an exceptionally high Na requirement. Under sub-optimal salinity, despite elevated concentrations of K and Mg, the loss of the driving force for water absorption due to Na deficiency resulted in impaired water uptake and growth stagnation. Under optimal salinity, through the high Na compartmentalization ability into vacuole and succulent diluting Na, S. edulis could accumulate it up to 15.3% dry base in leaf. Under high salinity conditions, enough Na accumulated in the leaves. This accumulation generates an osmotic gradient that facilitates water uptake. Consequently, leaf succulence gradually develops, allowing for the dilution of Na and enhancing the plant's ability to retain even more Na. Succulence not only reduces water loss from leaves but also minimizes excess light penetration, thereby suppressing the generation of reactive oxygen species. It is suggested that S. edulis possesses an exceptionally efficient ability to compartmentalize Na into vacuoles. During prolonged exposure, the water status recovered with the reduction of transpiration at supra-optimal salinity. However, it leads to oxidative stress initiation. At this level, the excess superoxide radicals were rapidly converted to H2O2 by the increased activity of superoxide dismutase (EC 1.15.1.1). The efficient antioxidative response played a crucial role on the plant's salt tolerance and acclimation. When Na levels are low, it was unable to absorb sufficient Na. The halophilic nature is supported by its salt tolerance function, which relies on the compartmentation of Na.