To ensure that groundwater is used in a sustainable manner, it is necessary to map, monitor and protect groundwater aquifers. Water scarcity is one of the most pressing global challenges of the twenty-first century that affects billions of people worldwide. One of the main challenges facing sustainable development in Egypt is the need for better growth and management of its limited freshwater resources. In Egypt, groundwater exists in the fringes of the Nile Valley, Nile Delta, Western Desert, and Sinai Peninsula. Groundwater Mapping is one of the main tools for groundwater exploration and one of the key components in strategic development projects. The hydrogeological map shows the geographical distribution of aquifers and their topographical, hydrogeological, hydrographical, hydrological and hydrochemical features. This chapter mainly presents the hydrogeological mapping for the New Delta Region (TheWestern Extension of Alexandria Region in theWestern Desert) illustrated in Al-Qahirah and Al-Alamayn map sheets, scale 1:250,000. Nine main layers are illustrated for the area under investigation. The layers are: hydrogeological units, lithological units, surface water, man-made features, groundwater features, topographic features, base of aquifer map, isopiezometric and isosalinity contour lines. In addition, descriptive text and land use maps for each map sheet are added to provide more illustrations and descriptions of the groundwater characteristics in the study area as well as the climatic conditions.