The Mesozoic-Cenozoic Tianshan orogenic belt, a key area for studying intracontinental orogenic deformation, experienced multiple uplift episodes due to the far -field effects from a series of collision events along the southern margin of Eurasia. Focusing on the fold-and-thwrust belt at the southern margin of the Bogda Mountain, a branch of the eastern Tianshan orogenic belt, we integrated 2D seismic data, borehole and outcrop data to construct a balanced and sequentially restored cross-section across the central part of this belt. The activities and mechanical evolution of the major faults were analyzed by using the discrete-element modeling (DEM) method, offering new insights into the tectonic transformation of the Turpan-Hami Basin influenced by episodic uplifts of the Bogda Mountain in an intracontinental setting. The studied fold-and-thrust belt can be divided into two deformation systems: (i) the piedmont deformation system, comprising a southward basement thrust system and a thin-skinned thrust system on Jurassic detachment, and (ii) the thrust front belt, exhibiting an en-echelon pattern in the basin center and featured by fault-propagation folds along the lower Jurassic coal unit. Stratigraphic and reported thermochronological analyses pinpoint four key contractional deformation periods: Late Jurassic, Late Cretaceous, Paleocene-Pliocene, and Pleistocene-present. The DEM numerical simulation results indicate a critical conical Coulomb wedge model governed by the episodic activities of the southern Bogda foldand-thrust belts from the Mesozoic to the Cenozoic. Surface processes (syntectonic erosion/deposition) significantly impacted differential activities between the orogenic belt and the basin ' s thrust structures. We propose that periodic arid climates in the Tianshan Mountains reduced erosion rates, promoting the expansion of the southern Bogda fold-and-thrust belts toward the basin and the widening of the orogenic belt.