Struthanthus (Loranthaceae) is native to the Americas, and several species occur in Mexico, some of which are endemic, such as S. palmeri. Within the genus, S. palmeri has the northernmost distribution, inhabiting the arid environments of northwestern Mexico near the border with the United States. In this study, the known distribution of the species was updated. The elevation, hosts, and vegetation types where S. palmeri occurs were compiled to infer its potential distribution, using ecological niche modeling. Based on the results, the endemic status of S. palmeri is reinforced. This taxon occurs in several types of vegetation, from near sea level to 1300 m, and it parasitizes taxa of 12 families. There are records of the species for 1 of the 21 federal Protected Natural Areas that are included in the "M area" employed in the analysis. The potential distribution of S. palmeri shows high probabilities of presence mainly in the North American Terrestrial Ecoregions that include the coastal areas of Sonora and Sinaloa. This study expands our knowledge of mistletoes from arid regions of America as well as our knowledge of Mexican endemic species, providing additional habitat and host information for the management and conservation of this group.