Seawater desalination using solar energy is a promising solution for addressing water scarcity in arid and semi-arid regions, as it not only provides a reliable source of fresh water, but also utilizes the abundant solar energy resources in the region to power the desalination process in a sustainable way. For this, the aim of this research is to investigate the performance and economic feasibility of a concentrated solar power plant coupled with a desalination unit for sustainable electricity and freshwater production. Six different coastal sites throughout the Middle East and North Africa region were considered, i.e., Agadir (Morocco), Algiers (Algeria), Sharm el-Sheikh (Egypt), Dammam (Saudi Arabia), Salalah (Oman), and Aden (Yemen). The concentrated solar power facility has a 100 MWe net output with two tanks of direct thermal energy storage using wet cooling with seawater as the cooling agent in the condenser; the solar tower model was validated using the Gemasolar power facility in Spain; and the desalination process include a direct-contact membrane distillation (DCMD) system numerically solved using the MATLAB software (R), with experimental data used to validate the model. The findings indicate that large-scale central receiver concentrated solar thermal facilities are more competitive in Sharm el-Sheikh, where annual energy output and capacity factor are expected to be 586.28GWh and 67%, respectively, while the cooling water demand is expected to be 1,793,310 m(3). The nominal levelized cost of electricity (LCOEnom) is 11.2 c/kWh. Furthermore, water production costs are <0.5 $/m(3) in Aden, Damman, Sharm el-Sheikh, and Salalah, but >1.0 $/m(3) in Agadir and Algiers. The results obtained indicate that the combination of these two tech-nologies can be a reliable source of power and fresh water for these locations.