We present stratigraphic, magnetic, diffuse reflectance spectrophotometric analyses, and chronologic data for the Chenarli loess-paleosol sequence in northeastern Iran. Eight loess units (LU) are identified, described, and constrained in time based on relative stratigraphy and luminescence dating from >130 +/- 9.1 ka to similar to 9.8 +/- 0.7 ka. Our data indicate that pedogenic magnetite/maghemite formation gives rise to magnetic enhancement in modern soil and paleosols. The top of LU 7 is demarcated by the well-developed last interglacial soil in which magnetic depletion occurred. We infer that magnetic depletion in this paleosol was produced by reducing conditions in a seasonally waterlogged soil during a warm and wet phase within Marine Isotope Stage (MIS) 5e. Units LU 6 to 1 record several episodes of dust accumulation and soil formation during the last glacial and Holocene. Increased dust accumulation rates occurred during middle-late MIS 3 and lasted into the late MIS 2, with a peak during the last glacial maximum (LU 2). These findings could be applicable to understanding magnetic enhancement/dissolution mechanism in the loess-paleosol sequences in study area. We infer paleoenvironmental changes in northeastern Iran relative to northern Iran, Eurasia, and China.