Ticks are obligate ectoparasites of domestic as well as wild animals all over the globe. Ticks are considered to be second most important ectoparasite after mosquitoes as vectors of diseases. The most commonly transmitted diseases are Crimean Congo hemorrhagic fever virus, Anaplasma, Borrelia, Rickettsia, Babesia spp., Francisela, Bartonella, Ehrlichia and Coxiella. Ticks have widely distributed in various areas of country but this is the only single and first study in the current area which was conducted in Tehsils Paharpur and Dera Ismail Khan to identify the tick genera. A survey was conducted to collect the tick from domesticated animals (buffaloes, cows, goats and sheep). The ticks were collected in collection vials containing 70% Ethyl Alcohol as preservative and brought to laboratory for identification. The identification of tick to genus level was done under microscope. Seven genera Rhipicephalus, Hyalomma, Haemaphysalis, Amblyomma, Dermacentor, Ixodes and Boophilus were identified in the current study. Tick infestation was recorded maximum in buffaloes followed by cows, sheep and goats. The most common tick species are assumed to be responsible for the transmission of tick-borne infections in addition to inflicting physical harm to the skin. The findings of current study provide additional information of tick genera and their infestation on domesticated animals, and will be helpful in adopting suitable management strategies against ticks on domestic animals.