Some herbicides, notably 2,4-D, are efficient at suppressing broadleaf weeds in wheat. No information is available on the effect of L. holosteoides on wheat yield losses. A variety of integrated nitrogen rates (0, 70, 140, and 210 kg N ha(-1) from urea) and postemergence herbicides (2,4-D+MCPA tank mixed with bentazon, bromoxynil+MCPA, bromoxynil +2,4-D, and bentazon+dichlorprop-p) were investigated in winter wheat for their effects on weed control, wheat growth, and yield. A split plot experiment with three replications was conducted in a semiarid environment in 2018-2020. Main-and sub-plots received nitrogen rates and herbicides. All attributes examined had no N-herbicide interactions. L. holosteoides was controlled best with 2,4-D+MCPA tank combined with bentazon (95%), followed by bromoxynil +2,4-D (84%), bentazon+dichlorprop-p (81%), and bromoxynil+MCPA (71%). L. holosteoides's dry weight and leaf area index were 6.67 g m(-2) and 0.049 with 2,4-D+MCPA and bentazon, respectively. Herbicides enhanced wheat output by 12 to 25%. For 60 L. holosteoides plants m(-2), grain yield dropped 25%. Overall, N rates had little influence on L. holosteoides growth and control. Moderate N treatment increased wheat's leaf greenness, area, grain yield, and yield components. The maximum grain yield (6428 kg ha(-1)) was achieved with the application of 147 kg N ha(-1) and bentazon+dichlorprop-p.