Physiological responses, root development, yield and growth of tomato (Solanum lycopersicum L.) (var. Tolstoy) to foliar applications of ZnSO4 during 2016 and 2017 cropping season was evaluated at high altitude cold-arid agro climatic conditions of Ladakh region. Field experiments were conducted with foliar spraying of ZnSO4@0.5% (T-1); 1.0% (T-2); 1.5% (T-3) and 2.0% (T-4) during flowering and fruit formation stage on tomato plants over control treatment (T-0). Results indicated that projected root area was highest in T-3 followed by T-4 treatment. The total yield of tomato was significantly increased from 34.3 and 38.1 t/ha without foliar application of Zn to 88.8 (1.5% Zn) and 77.4 t/ha (2.0% Zn) in 2016 and 2017, respectively. Average marketable yield in T-3 treatment was recorded 153% and 116% higher in comparison to T-0 in 2016 and 2017, respectively. Increase in dry biomass (52.21%) was also observed in T-4 over control treatment (T-0). Foliar application of Zn application also improved physiological parameters of tomato. Significant enhancement in leaf chlorophyll content, relative water content (RWC), membrane stability index (MSI) and significant reduction in electrolyte leakage (EL) was observed in T-3 and T-4 treatment. The results showed that foliar application of ZnSO4@1.5% significantly improved growth, development and yield of tomato at cold desert Ladakh region.