Zinc deficient soils cause low crop production leading to malnutrition in humans and livestock. Two years field experiments were conducted on cowpea crop with six ZnSO(4)Greek ano teleiaH(2)O (33%) treatments viz. no Zn, soil application of 16 kg ZnSO(4)Greek ano teleiaH(2)O ha(-1) (S-Zn), one foliar spray of 0.3% ZnSO(4)Greek ano teleiaH(2)O at early bloom (EB) stage (F-1Zn), two foliar sprays of 0.3% ZnSO(4)Greek ano teleiaH(2)O at EB and full bloom (FB) stages (F-2Zn) and combination of soil application + foliar sprays of ZnSO4.H2O (S-Zn+F-1Zn and S-Zn+F-2Zn) were tested. The results showed that soil application of 16 kg ha(-1) of ZnSO(4)Greek ano teleiaH(2)O followed by two foliar sprays of 0.3% ZnSO(4)Greek ano teleiaH(2)O at EB (R1) and FB (R2) stages recorded maximum increase in grain yield (43.7%) and grain Zn content (22.7%) over control. However, in straw, a three-fold increase in Zn content was recorded. Foliar applications of 0.3% ZnSO(4)Greek ano teleiaH(2)O at EB and EB+FB stages recorded a significant increase in grain (8.2% and 11.4%) and straw Zn content (63.0% and 104.0%) over control. In conclusion, combination of soil (S-Zn) + foliar (F-2Zn) Zn application method was most remunerative with maximum production and monetary efficiencies (15 kg ha(-1) day(-1) and $7.5 ha(-1) day(-1)) and is an effective approach for grain and straw Zn biofortification in cowpea.