In Maize-Wheat rotation, nitrogen fertilization plays a critical role in increasing grain yield, and the high N usage efficiency is the key to achieve such increases. Sulphur fertilization has been shown in many trials to improve NUE. The importance of balanced nutrient supplementation for improved crop production is widely acknowledged. Thus, the current study is a trial to find out the proper N:S ratio needed to improve wheat-maize productivity. To attain this aim, a field study was conducted at two different locations (Peshawar, semi-arid, hot and Buner, sub-humid, comparatively cooler) while considering the following treatments (individually or in combinations): N inputs were supplied in the form of urea at three different rates (i.e. 90, 120 and 150 kg ha(-1)) while S was applied as elemental sulphur in four different rates (i.e 0, 20, 40 and 60 kg ha(-1)). Factorial arrangement in RCB Design was followed with three replications. The key results showed that nitrogen (N) and sulphur (S) significantly improved the productivity of maize and wheat at both locations, (i.e biological yield, grain yield and 1000 grain weight of maize and wheat). In Peshawar, maximum crop productivity was recorded with supplementation of 150 kg N ha(-1) and 20 kg ha(-1) S while in Buner maximum crop productivity was recorded with 150 kg N and 40 kg S ha(-1) application. The availability of S was more pronounced at Peshawar as compared to district Buner. The highest uptake of N was recorded for the application of 150 kg N ha(-1) while the highest S uptakes were noticed with the application of 60 kg ha(-1) S. The interaction between N and S have significantly affected crop productivity and soil fertility where there best combination which were noticed with the supplementation of 150 kg N ha(-1) in combination with 20 kg S ha(-1) at Peshawar while, the combination needed at Buner was 150:40 (N:S).