DOI
10.1186/s12889-024-17682-z
Metabolic syndrome increases osteoarthritis risk: findings from the UK Biobank prospective cohort study
作者地址
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Joint Surg, Guangzhou 510080, Guangdong, Peoples R China
通讯作者
Zhang, Ziji;Xia, Bin;Wei, Fuxin
摘要
ObjectiveThe association between Metabolic Syndrome (MetS), its components, and the risk of osteoarthritis (OA) has been a topic of conflicting evidence in different studies. The aim of this present study is to investigate the association between MetS, its components, and the risk of OA using data from the UK Biobank.MethodsA prospective cohort study was conducted in the UK Biobank to assess the risk of osteoarthritis (OA) related to MetS. MetS was defined according to the criteria set by the International Diabetes Federation (IDF). Additionally, lifestyle factors, medications, and the inflammatory marker C-reactive protein (CRP) were included in the model. Cox proportional hazards regression was used to calculate hazard ratios (HR) and 95% confidence intervals (CI). The cumulative risk of OA was analyzed using Kaplan-Meier curves and log-rank tests. To explore potential nonlinear associations between MetS components and OA risk, a restricted cubic splines (RCS) model was employed. In addition, the polygenic risk score (PRS) of OA was calculated to characterize individual genetic risk.ResultsA total of 45,581 cases of OA were identified among 370,311 participants, with a median follow-up time of 12.48 years. The study found that individuals with MetS had a 15% higher risk of developing OA (HR = 1.15, 95%CI:1.12-1.19). Additionally, central obesity was associated with a 58% increased risk of OA (HR = 1.58, 95%CI:1.5-1.66), while hyperglycemia was linked to a 13% higher risk (HR = 1.13, 95%CI:1.1-1.15). Dyslipidemia, specifically in triglycerides (HR = 1.07, 95%CI:1.05-1.09) and high-density lipoprotein (HR = 1.05, 95%CI:1.02-1.07), was also found to be slightly associated with OA risk. When stratified by PRS, those in the high PRS group had a significantly higher risk of OA compared to those with a low PRS, whereas no interaction was found between MetS and PRS on OA risks. Furthermore, the presence of MetS significantly increased the risk of OA by up to 35% in individuals with elevated CRP levels (HR = 1.35, 95% CI:1.3-1.4).ConclusionMetS and its components have been found to be associated with an increased risk of OA, particularly in individuals with elevated levels of CRP. These findings highlight the significance of managing MetS as a preventive and intervention measure for OA.
资助信息
National Natural Science Foundation of China (No.81972135), the Natural Science Foundation of Guangdong Province (no. 2022A1515012279, 2021A1515010335), Funds for Shenzhen Social Science and Technology Development (no. JCYJ20190812093401685), Funds for Part-time principal investigator of the Seventh affiliated hospital of Sun Yat-sen University (no. ZSQYJZPI202005), and Sanming Project of Medicine in Shenzhen (no.SZSM201911002).
资助机构
国家自然科学基金委员会
;
深圳市科技厅
;
中山大学附属第七医院
WOS学科分类
Public, Environmental & Occupational Health
WOS关键词
C-REACTIVE PROTEIN
;
KNEE OSTEOARTHRITIS
;
INFLAMMATION
;
INDIVIDUALS
;
DISEASE
;
BURDEN
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