Lanzhou Univ, Hlth Technol Assessment Ctr, Evidence Based Social Sci Res Ctr, Sch Publ Hlth, 199 Donggang West Rd, Lanzhou 730000, Peoples R China
通讯作者
Yang, Kehu;Li, Xiuxia
来源期刊
Drug Alcohol Depend
ISSN
0376-8716
EISSN
1879-0046
出版日期
2022-11-01
卷号
241
摘要
Background: Based on randomized controlled trials, a network meta-analysis was conducted to compare treatment effects across varenicline and related smoking interventions. Methods: English databases were screened for randomized controlled trials reporting the effect of varenicline as treatment for smoking. The risk of bias in included trials was assessed using the Cochrane Handbook tool. Stata 15.1 software was used to perform network meta-analysis, and the GRADE approach was used to assess the evidence credibility on the tobacco treatment effects of different interventions. Results: Thirty-four studies involving 26,130 smokers were included in the network meta-analysis. Varenicline and 11 other interventions were reported, yielding 66 pairs of comparisons. Network meta-analysis showed that varenicline monotherapy or its combination with other interventions were superior in achieving smoking cessation compared to bupropion, nicotine replacement therapy, counselling, and placebo. Furthermore, compared to the varenicline, evident abstinence superiority was found in varenicline + bupropion (odds ratio = 1.49, 95% confidence interval [1.02, 2.18]). Finally, the surface under the cumulative ranking curve value indicated that varenicline + bupropion has the highest probability to become the best intervention. Conclusions: Varenicline monotherapy increased the odds of smoking cessation further than bupropion monotherapy, nicotine replacement therapy, counselling, and placebo, while varenicline combined with other interventions may even achieve a better abstinence effect. More credible evidence has been reported indicating that the combination of varenicline and bupropion is a superior treatment for smoking.
National Natural Science Foundation of China (Project No. 72074103);the Fundamental Research Funds for the Central Universities: lzujbky-2021-ct06 lzujbky-2021-kb22;the Gansu Special Project of Soft Science (20CX9ZA109).
资助机构
National Natural Science Foundation of China (NSFC)
;
Fundamental Research Funds for the Central Universities
