兰州大学循证社会科学交叉创新实验室 Innovation Laboratory of Evidence-based Social Sciences,Lanzhou University

A Systematic Review of COVID-19 and Kidney Transplantation

Viyaasan Mahalingasivam
2021-01-01
Introduction Kidney transplant recipients are at increased susceptibility to many viral infections leading to justifiable anxiety about the effects of coronavirus disease 2019 (COVID-19). Methods We performed literature searches from multiple resources in April and August 2020 for relevant English and Chinese literature. Abstracts were screened, followed by full-text review with data extraction of reports that included at least 20 kidney transplant recipients with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and completed outcomes. Results Twenty studies had sufficient data, which we have summarized. Studies were predominantly descriptive and came from France, Italy, Spain, Turkey, United Kingdom, and United States. Quality assessment demonstrated limitations in selection of comparison groups and controlling for additional factors. Mortality rates from published studies were variable. Based on early data early from Spain, 46% of patients who developed COVID-19 within 60 days of transplantation died. Acute kidney injury was common, and mycophenolate was discontinued in most patients. Conclusion Given the rapid global spread of COVID-19, reliable evidence is needed to inform public health policies. Hospitalized kidney transplant recipients with COVID-19 are at a high risk of death in early reports but interpretation of these data requires caution, as studies were susceptible to period effects. Reassuringly, the quality of observational data is improving. Detailed and comprehensive data collection through linked registries will be necessary to conduct accurate analyses of risk factors for adverse outcomes, not least given the risks of stopping imunosuppression. This report highlights the early mortality excess in transplant recipients but medium- and longer-term outcomes remain uncertain and merit careful investigation.
Kidney International Reports
卷号:6|期号:1|页码:24-25
ISSN:2468-0249|收录类别:SCIE
DOI
DOI: 10.1016/j.ekir.2020.10.023
EISSN
NR
出版日期
2021-01-01
资助信息
NR
资助机构
NR
相关链接
https://www.sciencedirect.com/science/article/pii/S2468024920316934?via%3Dihub
语种
英语
国家
英国
学科领域
循证医学
WOS学科分类
Urology & Nephrology
被引频次(WOS)
65
来源机构
兰州大学循证社会科学研究中心
研究类型
系统评价
关键词
COVID-19 kidney transplantation systematic review